Cellular RNAs are extensively decorated with chemical modifications that fine-tune gene expression at multiple levels. Among these, N6-methyladenosine (m6A) emerges as the most abundant internal mark ...

Accurate RNA splicing is essential for gene expression and human health, yet predicting how DNA sequence variations affect ...

In back-to-back studies published in Nature, researchers from Purdue University and Columbia University report a naturally evolved gene-editing system that can activate genes, offering an advantage ...

The cover of Aging-US Volume 17, Issue 12, features Figure 5 from the research paper, titled "A combination of differential expression and network connectivity analyses identifies a common set of RNA ...

A new research paper featured as the cover of Volume 17, Issue 12 of Aging-US was published on December 22, 2025, titled "A combination of differential expression and network connectivity analyses ...

In the study of bacteria, a longstanding dogma has held that two molecular machines—RNA polymerase, which leads the way in ...

As nucleic acid–based therapeutics evolve and mature, so too must the analytical tools that are designed to characterize them. New microfluidic capillary electrophoresis (CE) methods that are designed ...

Omics technologies have enabled researchers to study the molecular functions of human tissues. But some tissues—like the brain—are harder to access than others. Because of the limited access to living ...

A new spatial transcriptomic approach captures the regulation of splicing and polyadenylation sites during pubescent brain development at near-single-cell resolution. An international collaboration, ...

Two new research papers from the Living Brain Project at Mount Sinai present what is, by several metrics, the largest investigation ever performed of the biology of the living human brain. The papers ...

It may be time to rethink certain genetic mutations associated with two devastating neurodegenerative disorders—amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)—according to a new ...