Adult cardiomyocytes are postmitotic cells that undergo very limited cell division. Thus, cardiomyocyte death as occurs during myocardial infarction has very detrimental consequences for the heart.

Since 1998, more Foreign Service Nationals have been killed in the line of duty than US members of our foreign service. “Localization” is the latest buzzword in foreign assistance. But in one sense, ...

Atherosclerosis is a chronic inflammatory disease causing a fatal plaque rupture, and its key aspect is a failure to resolve inflammation. We hypothesize that macrophage-targeted near-infrared ...

Single-molecule localization microscopy (SMLM) describes a family of powerful imaging techniques that dramatically improve spatial resolution over standard, diffraction-limited microscopy techniques ...

We introduced enhanced UnaG (eUnaG), a ligand-activatable fluorescent protein, for conventional and super-resolution imaging of subcellular structures in the mammalian cells. eUnaG is a V2L mutant of ...

Imaging technologies are central platforms that drive fundamental research in virtually all disciplines across the life sciences. In neuroscience, confocal microscopy constituted the standard ...

Regulation of molecular transport via intercellular channels called plasmodesmata (PDs) is important for both coordinating developmental and environmental responses among neighbouring cells, and ...

Neurological disorders display a broad spectrum of clinical manifestations. Yet, at the cellular level, virtually all these diseases converge into a common phenotype of dysregulated synaptic ...

We developed a small protein tag enabling fluorescent labeling of proteins in living cells and in multicellular organisms through the specific binding and activation of a cell-permeant and nontoxic ...

Large and complex macromolecular assemblies—like RNA and DNA polymerases, the kinetochore, the ribosome, ATP synthase, and many others—are critical components of the cell. To fully characterize these ...