The DNA replication simulator is a tool that lets you see the entire process of DNA being copied during cell division in real-time animation. You can intuitively understand the entire sequence, from ...

The discovery of DNA ligase by the Gellert, Lehman, Richardson, and Hurwitz teams in 1967 was a breakthrough in molecular biology. These essential enzymes maintain genome integrity and play a vital ...

DNA might not seem like a common link between humans and the microorganisms responsible for your morning toast, but recent research reveals a surprising connection. Humans and baker’s yeast share more ...

New findings suggest the end-replication problem, an old standby of biology textbooks, is twice as intricate as once thought. Half a century ago, scientists Jim Watson and Alexey Olovnikov ...

DNA replication is required to maintain the integrity of genomic information. This article describes the process of DNA replication, in a step-by-step manner. DNA replication requires unwinding of the ...

The DNA sliding clamp proliferating cell nuclear antigen (PCNA) is an essential co-factor for many eukaryotic DNA metabolic enzymes. PCNA is loaded around DNA by the ATP-dependent clamp loader ...

DNA replication is an essential and tightly regulated process that follows several ordered steps occurring at the S phase of the cell cycle. Replication is triggered after replication origins are ...

The helicase unzips the double-stranded DNA for replication, making a forked structure. The primase generates short strands of RNA that bind to the single-stranded DNA to initiate DNA synthesis by the ...

During the S phase of the cell cycle, the DNA replication machinery accurately duplicates the genome in spite of numerous hurdles that cause replication stress. The replication checkpoint pathway ...

As faithful DNA replication is a crucial process for genetic inheritance, the accurate copying of epigenetic information is vital for maintaining cell lineage. It is well known that DNA polymerases ...