Accurate RNA splicing is essential for gene expression and human health, yet predicting how DNA sequence variations affect ...

All living organisms are known to inherit genes, DNA sequences that contain instructions for producing specific proteins and ...

Time-series spatial transcriptomics (ST) data can show dynamics of biological structures in situ. Here, the authors present an algorithm for cellular trajectory inference from time-series ST that ...

New methods for analyzing RNA-Seq data enable de novo reconstruction of the transcriptome. There are also notable differences in the details of the algorithms. For example, Cufflinks uses a rigorous ...

RNA-seq has represented a pivotal breakthrough in transcriptomics. Among the successful factors of this technology, two features have had the highest impact: the capability of measuring the whole ...

python 2.7.x (numpy, scipy, seaborn, pyBigWig, statsmodels, pysam) IEDB stand-alone (Note: IRIS is only tested on 20130222 2.15.5) Snakefile describes the IRIS pipeline. The configuration for running ...

Alzheimer’s blood test breakthrough: 34 circular RNA biomarkers validated in nearly 2,400 patients outperform the pTau217 ...

In cancer research, one person's junk is increasingly becoming another person's treasure. Scientists have now uncovered new evidence showing how recently evolved "junk DNA" genetic elements can become ...

The prevalence of collective cancer invasion as a mechanism of cancer metastasis is widely reported, but the regulatory mechanisms at the invading fronts of tumors remain largely unknown. Conflicting ...

Pre-mRNA splicing is a fundamental process that shapes gene expression and proteome diversity, yet how it integrates with physiological pathways in plants remains poorly understood. Our study ...