The concept of trained immunity has redefined innate immune responses as adaptable, durable, and context dependent. Natural killer (NK) cells, traditionally ...

Distant metastasis and recurrence remain major obstacles limiting the long-term efficacy of immunotherapy for solid tumors, particularly in highly aggressive cancers, such as malignant melanoma.

The BCG vaccine protects against tuberculosis, but by inducing trained immunity it also protects against many more respiratory infections. International research led by Radboud University Medical ...

When a transplanted organ arrives, it’s like a controlled burn that risks becoming a wildfire. The body’s innate immune system senses damage signals, like heat shock proteins (HSP70), and sounds the ...

Monocytes are central to innate and adaptive immunity, regulating tissue homeostasis and inflammation. However, data on their ...

Aquatic crustaceans, including shrimps, crabs and crayfish, rely exclusively on innate immunity to counter a broad spectrum of pathogens in marine and freshwater environments. Their first line of ...

Mammalian immunity has long been thought to rely solely on proteins and specialized immune cells. However, a newly proposed concept—RNA immunity—is reshaping this perspective. In a recent publication ...

Findings from St. Jude Children's Research Hospital demonstrate that virtual memory T cells, a specialized group of immune cells, provide nonspecific immunity for infants early in life. The work stems ...

It starts with a sneeze. Someone on the subway didn't cover their mouth and now a cloud of invisible invaders hangs in the air. Before you even step off the train, your immune system has already begun ...

It starts with a sneeze. Someone on the subway didn't cover their mouth and now a cloud of invisible invaders hangs in the air. Before you even step off the train, your immune system has already begun ...