You are free to share (copy and redistribute) this article in any medium or format within the parameters below: Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must ...

STING is an essential adaptor protein required for the inflammatory response to cytosolic DNA. dsDNA activates cGAS to generate cGAMP, which binds and activates STING, triggering oligomerization, IRF3 ...

In early development, the environment triggers mnemonic epigenomic programs resulting in memory and learning experiences to confer cognitive phenotypes into adulthood. To uncover how environmental ...

F. Hoffmann-La Roche Ltd., pRED, Pharma Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland *H.R.: e-mail ...

Previously, the lack of methods that would allow for direct and quantitative measurement of drug-target engagement in live cells with temporal resolution considerably limited our ability to better ...

Many of our instrument techniques rely on a calibration in order to relate the detector response to the amount of analyte within our sample. Many of our instrument techniques rely on a calibration in ...

Diversity indices are widely used in ecology to describe differences in microbial or plant communities, but are rarely applied to investigate variability in decomposing soil organic matter (SOM) ...

Biologists entering liquid chromatography?mass spectrometry (LC?MS) from a background of general LC rarely use their mass spectrometer to its full potential. Isotope peaks offer huge possibilities ...