Toll-like receptor 4 (TLR4) is a pattern recognition receptor central to innate immunity. It recognises lipopolysaccharide (LPS), an outer-membrane component of Gram-negative bacteria, via a ...

Innate immune signalling through Toll-like receptors (TLRs) constitutes the frontline defence against microbial invasion. Each TLR recognises distinct pathogen-associated molecular patterns and ...