Accurate RNA splicing is essential for gene expression and human health, yet predicting how DNA sequence variations affect ...

Cellular RNAs are extensively decorated with chemical modifications that fine-tune gene expression at multiple levels. Among these, N6-methyladenosine (m6A) emerges as the most abundant internal mark ...

In back-to-back studies published in Nature, researchers from Purdue University and Columbia University report a naturally evolved gene-editing system that can activate genes, offering an advantage ...

The cover of Aging-US Volume 17, Issue 12, features Figure 5 from the research paper, titled "A combination of differential expression and network connectivity analyses identifies a common set of RNA ...

A new research paper featured as the cover of Volume 17, Issue 12 of Aging-US was published on December 22, 2025, titled "A combination of differential expression and network connectivity analyses ...

As nucleic acid–based therapeutics evolve and mature, so too must the analytical tools that are designed to characterize them. New microfluidic capillary electrophoresis (CE) methods that are designed ...

RNA splicing, in which different coding RNA, or exons, are joined together after noncoding regions, or introns, are removed, allows for a large array of RNA transcript isoforms with distinct sequences ...

Two new research papers from the Living Brain Project at Mount Sinai present what is, by several metrics, the largest investigation ever performed of the biology of the living human brain. The papers ...

It may be time to rethink certain genetic mutations associated with two devastating neurodegenerative disorders—amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)—according to a new ...

Emerging gene-editing platforms are demonstrating that disease-causing mutations, aberrant gene expression, and even large-scale DNA insertions can be corrected without relying on error-prone DNA ...

In Alzheimer’s disease and other tauopathies, accumulating tau fibrils track closely with neurodegeneration and clinical decline. Yet, exactly how, or even if, certain tau aggregates are toxic to ...