Fructose, a monosaccharide abundant in diet and generated endogenously via the polyol pathway, has emerged as a key substrate in cancer cell metabolism. Tumours frequently upregulate specific ...

The TRα1 nuclear receptor is the principal mediator of the thyroid hormone actions in the small intestinal and colonic mucosae. TRα1 is expressed in colon epithelial and stromal cells and is increased ...

For years, one of the most powerful weapons against certain blood cancers, called CAR-T therapy, has required an elaborate process: Doctors extract a patient’s immune cells, ship them to a specialized ...

(a) A scanning electron microscope (SEM) image of the nanoneedle probe used for the measurements. (b) Elasticity map of a 1 µm × 1 µm area on the nuclear surface, showing the change in elasticity ...

Cancer cells provide healthy neighboring cells with additional mitochondria to put them to work. This has been demonstrated by researchers at ETH Zurich in a new study. In this way, cancer is ...

Cancer cells can brainwash their neighbors. Like the CIA deploying secret agents to turn an enemy, tumors use a similar strategy to manipulate nearby cells. The tumors’ agents are mitochondria, the ...

A small number of cancer cells with the ability to change their identities and behaviors appear to be a key driver of cancer progression and its ability to evolve resistance to treatment. Targeting ...

Cancer cells are known for their “glutamine addiction,” but many can escape this weakness by switching to alternative fuels. Researchers found that vitamin B7 acts like a metabolic “license,” enabling ...

Scientists have identified a new weakness in harmful "zombie-like" cells that could open the door to better cancer treatments and therapies for age-related diseases. These cells, known as senescent ...