Structure-based drug design (SBDD) aims to design small-molecule ligands that bind with high affinity and specificity to pre-determined protein targets. Generative SBDD methods leverage structural ...

Fragment-based drug discovery has been an effective paradigm in early-stage drug development. An open challenge in this area is designing linkers between disconnected molecular fragments of interest ...

How model-based systems engineering (MBSE) has improved system design. Thermal design and MBE come together. When considering systems-level design, it’s important to understand the criticality of the ...

Heavy machinery is entering a new phase where hydraulics, electronics and embedded software are engineered as one integrated system. Using model-based systems engineering (MBSE) as a framework to ...

Why engineers are turning to system-level models. How high-fidelity digital twins help expose system-level issues. Where MBSE is experiencing the fastest adoption. The roles of AI and data science in ...

The so-called V-model provides many benefits for organizing the system engineering perspective by depicting the orderly progression, from requirements definition to system-level specification, ...

Well, we already have a thriving thread on how AI is going to change how SW gets written. Figured it's worth exploring a discusison on how MBSE is going to change how Systems work is done. Honestly, I ...