Histones are perhaps more intimately linked with DNA than any other protein. Transcriptional regulation, recombination, repair, and replication--basically anything that happens to the DNA--must happen ...

1 Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA 2 Department of Chemistry, Princeton University, Princeton, NJ 08544, USA Histone post-translational modifications ...

Histone post-translational modifications (PTMs) comprise one of the most intricate nuclear signaling networks that govern gene expression in a long-term and dynamic fashion. These PTMs are considered ...

Tsukuba, Japan—In eukaryotes, genomic DNA, which is a very long double helix containing all the genetic information, wraps around a globular protein called a histone and folds it many times before ...

The histone code hypothesis posits that distinct combinations of histone modifications can recruit chromatin-modifying enzymes and exert epigenetic control over heterochromatin assembly. In the March ...