核酸适配体（Aptamer）是一类短的单链 DNA 或 RNA ...

基因编辑，特别是最新的碱基编辑技术，能像“分子铅笔”一样直接改写DNA上的单个字母（碱基），理论上比直接切断DNA的Cas9更安全、精准。但“脱靶”问题始终如影随形。准确找出所有脱靶位点，如同在茫茫基因组中寻找几个拼写错误，极其困难。

Find how Circularization for High-throughput Analysis of Nuclease Genome-wide Effects by Sequencing Base Editors ...

CHANGE-seq-BE was developed to enable scientists to better understand base editors, an important class of CRISPR precise genome editors.