Srinivasu Karri is a postdoctoral researcher at the University of Minnesota. He investigates how cells accurately recycle parental histones during DNA replication to maintain critical chromatin states ...

It has been hypothesized that the inheritance of epigenetic traits, such as DNA methylation, may be more prevalent than is currently established 1,2. This phenomenon could help explain poorly ...

When we think about genetic inheritance, we usually leap to DNA, the four-letter code containing the instructions for building a living organism. Scientists know that DNA encodes everything from hair ...

Allele-specific DNA methylation reflects genetic variation and parentally-inherited changes, and is involved in gene regulation and pathologies. Yet, our knowledge of this phenomenon is largely ...

Lamia Wahba is studying how information outside the genetic code can pass between generations and what that means for evolution and disease. When we think about genetic inheritance, we usually leap to ...

The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

Every day, billions of cells in your body divide, helping to replace old and injured cells with new ones. And each time this happens, your entire genetic library—your genome, which totals more than 3 ...

Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...

Drs Ursula A. Matulonis and Joyce F. Liu discuss targeting DNA damage and repair and replication stress in endometrial cancer. Drs Ursula A. Matulonis and Panagiotis A. Konstantinopoulos discuss ...

Scientists uncovered DNA's double helix structure in 1953. James Watson and Francis Crick proposed the model. It explained ...