It's no coincidence that our bodies feel a little creakier as we age. The trillions of cells that make up our skeleton age too, and some change in ways that weaken the very structure of our bones.

Muscle and bone constitute a multifunctional unit whose integrity is maintained through both mechanical forces and biochemical signalling. Mechanical loading generated by muscle contraction imposes ...

Animal bodies are hierarchically organised from molecules and cells through tissues, organs and whole systems. Cellular architecture—membranes, cytoskeletons and extracellular matrices—provides ...

A recent study has uncovered the essential roles of two proteoglycans, biglycan and decorin, in maintaining bone mass, water retention, and bulk/in situ mechanical competence. Through the use of ...

Bone tissue is a complex structure, consisting of mineralized collagen fibers and a variety of non-collagenous proteins, including proteoglycans such as biglycan and decorin. These proteoglycans ...