Bone morphogenetic proteins (BMPs) are secreted growth factors belonging to the transforming growth factor-β superfamily that orchestrate the formation, growth and maintenance of the vertebrate ...

Notch signalling is a highly conserved cell-to-cell communication pathway that orchestrates cell fate determination, proliferation and differentiation within the skeletal system. Activation occurs ...

Stem cells form the backbone of many cell-based therapies due to their unique properties, including the ability to self-renew and differentiate to many cell types. Multiple cell therapies deliver ...

Indiana University School of Medicine scientists have developed a powerful new imaging technique to study bone marrow in mouse models. By overcoming key challenges unique to imaging this complex ...

Pilot studies have shown encouraging results that are supporting the company’s pre-IND enabling development, marking a critical step toward clinical translation of the Bone Marrow Organoid technology ...

Skeletal conditions such as developmental dysplasia of the hip (DDH), osteoporosis, and osteoarthritis affect millions worldwide, often causing chronic pain and disability. These disorders stem from ...

SSCs are heterogeneous in nature, contributing to the development of long bones, craniofacial structures, and the spine. These SSCs have important functions in a variety of physiological and ...

Data from the long-running HOME study links higher exposure to certain polyfluoroalkyl substances ‘forever chemicals’ with ...

Bone-destructive diseases such as osteoporosis and chronic inflammatory arthritis affect millions of people worldwide, causing pain, fractures, and decreased quality of life. These conditions often ...

Scientists have identified a protein that blocks the activity of bone-forming cells (osteoblasts) by stopping them from maturing during the journey to sites of bone formation, a new study has found.

Early-life exposure to per- and polyfluoroalkyl substances (PFAS) may influence how children's bones develop during adolescence, according to new research published in the Journal of the Endocrine ...

Bone spurs are smooth bony projections that form along joint edges, often due to ageing, osteoarthritis, injury, or ...