Bone tissue engineering harnesses the regenerative potential of stem cells to restore or replace damaged skeletal structures. Central to this endeavour are multipotent mesenchymal stem cells (MSCs) ...

(Nanowerk Spotlight) Surgeons treating large bone defects—whether after tumor removal, traumatic injury, or severe infection—face a material problem with few good options. After clearing the damaged ...

Bone implants often fail to fully integrate with surrounding tissue, limiting their effectiveness in regeneration. A natural but often overlooked cellular process could hold the key to better outcomes ...

A single-atom nanozyme mimicking cytochrome c oxidase restores mitochondrial energy production in stem cells, shifting their metabolism to accelerate bone regeneration in critical-sized defects.

Researchers found that mice lacking membrane ERα signaling in osteoblast lineage cells had significantly lower cortical bone mass, highlighting the pathway’s critical role in maintaining the strength ...

Schematic diagram illustrating how transplanted young mitochondria activate the AKAP1/cAMP/PKA pathway in aged PDLSCs, restoring mitochondrial membrane potential (ΔΨm), reducing ROS, and enhancing ...